Simultaneous car bombings in a mostly Christian and Druze town near Damascus killed at least 38 people as rebels downed a military aircraft for the second successive day.
The blasts occurred when explosives-packed cars were detonated at daybreak on Wednesday in a pro-regime area of the town of Jaramana, residents, state media and a rights watchdog reported.
They were the fourth bomb attacks since August 28 to rock Jaramana, home to predominantly Christians and Druze, an influential minority whose faith is an offshoot of Shi'ite Islam.
Sectarian divides are a key factor in Syria's armed rebellion, with many in the Sunni Muslim majority frustrated at more than 40 years of Alawite-dominated rule.
The blast ripped through a central square of Jaramana, said the official SANA news agency.
There was a ball of fire at the end of a narrow lane, and the impact of the explosions brought walls down onto cars, crushing them and scattering debris over the ground. Pools of blood were seen in the middle of the street.
The death toll mounted as the morning wore on, with the Syrian Observatory for Human Rights giving tallies of 20, then 29 and finally at least 38. The interior ministry put the count at 34.
"Activists and residents in the town said most of the victims were killed when a suicide attacker blew up his car, just after an explosive device was used to blow up another car," said the Observatory.
SANA reported that "terrorists" blew up the two car bombs at the same time, as two separate explosive devices were set off without claiming any lives.
The Syrian uprising erupted in March 2011 with peaceful pro-democracy protests, inspired by the Arab Spring. It transformed into an armed insurgency when the government began a bloody crackdown on dissent.
The regime of President Bashar al-Assad, himself an Alawite, insists it is fighting foreign-backed "terrorists".
The failure of international diplomacy has enabled it to press on with its all-out military campaign to crush the rebellion, and the fighting has resulted in more than 40,000 deaths, according to the Observatory.
In the latest violence, an AFP correspondent on the Syria-Turkey border reported that rebel fighters shot down a fighter jet in the embattled northwest.
The warplane came down in a massive explosion, leaving behind a plume of smoke, the journalist said, reporting several kilometres away from the impact.
The aircraft was hit by a missile and crashed at Daret Ezza, said the Observatory, a Britain-based watchdog that relies on a network of activists and medics on the ground for its information.
It came a day after rebels downed an army helicopter for the first time with a newly acquired ground-to-air missile, in what the Observatory said had the potential to change the balance of military power in the conflict.